Fat Genes

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Fat Genes!??
Article by George Pierce
big pants
due to weight loss
Do Fat Jeans come from Fat Genes?

 Do Fat Genes Even Exist?
Are Fat Genes Responsible For Obesity?
What Are Fat Genes?


  Do Fat Genes Exist?

Scientists are telling us that there really are such things as fat genes.  Evidence indicates that science has already found  over 100 fat genes. 

Presently there are two fat genes that are getting all the news and all the attention.

If there are genes that do cause weight gain, they can be treated. 

One of the genes is called the FTO Gene the other is called ankyrin B

FTO Gene:

The FTO Gene was discovered about 10 years ago.  In order for your to be a 'carrier', you need to receive the gene from both your mother and your father.  In other words you need two variants in order to be a carrier.  The faulty gene is believed to be responsible for turning energy from food into fat rather than burning it as fuel. 

If you do have the FTO Gene, research shows that the gene is responsible for an average of seven additional pounds.  If you are a carrier, you will probably weigh about seven pounds more than those without the gene.  Even a mere seven pounds of additional weight can be unhealthy.

The good news is that studies show that people with the gene have no more difficulty losing weight than those without the gene.  (See Time Says "Don't Blame Your Genes!")

Information that I find disturbing about the FTO Gene linked with ANKK1 Gene is that it seems to affect D2R (dependent reward learning). 

A study published by the Journal Of Neuroscience http://www.jneurosci.org/content/35/36/12584,  showed a reduced ability for avoidance learning which may contribute to obesity as well as other disorders such as substance abuse and pathological gambling. 

Avoidance learning?  We learn from both positive and negative situations, at least, we are supposed to.  An example of avoidance learning would be a mouse that persists on grabbing a treat while being shocked.  It might mean not avoiding foods that we know will add weight.  

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ankyrin B Gene

Recent research at Duke University shows that a variant of a gene called ankyrin B causes cells to absorb glucose at a faster than normal rate.  In mice, when the variant gene led to obesity.  https://www.sciencedaily.com/releases/2017/11/171113153824.htm
Presently the defective gene has been studied only in mice.  The findings are NOT yet confirmed in the general public.

In mice, the variant caused weight gain for mice that at the same amount of food as other mice. 

It is estimated that about 1.3% of Caucasians and 8.4% of African Americans have this variant. 

These percentages could mean that almost 10% of the human population are overweight through no fault of their own.  Presently, there is ZERO proof and NO clinical or scientific evidence to confirm that these findings apply to humans. 

In addition, almost 70% of the human population is overweight or obese, not 10%. 

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Please be careful about what you read about fat genes and please consider the source.  I share this warning for your own benefit.  Why?  The weight loss industry and the drug industry are already looking for ways to pounce on this opportunity. 

The fact that weight loss is not affected and that the weight difference seems to be a mere seven pounds does not matter. 

The idea that they want to sell you on is the notion 'these genes can be treated or fixed and that they have the drug or the pill that will treat it!'   

So my conclusion is to be careful.  A drug or pill may do you harm as well as cost you money and may or MAY NOT solve an almost non-existent problem.

My friends, thank you for reading.  I wish you success on your weight loss journey.

George Pierce
Win At Losing Weight Founder


Meal Planning Made Simple

Genetic HUMOR!

Maybe Genetics Has Nothing To With It!

The answer to cardiovascular genetics:

The Japanese eat very little fat and suffer fewer heart attacks than the British or Americans.

On the other hand, the French eat a lot of fat and also suffer fewer heart attacks than the British or Americans.

The Japanese drink very little red wine and suffer fewer heart attacks than the British or Americans.

The Italians drink excessive amounts of red wine and also suffer fewer heart attacks than the British or Americans.

Conclusion: Eat and drink what you like. It is speaking English that kills you.

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not too fat weight joke

Time Magazine Says "Don't Blame Your Genes!"

There seems to be several different points of view regarding the Fat Genes.  One point of view is that our genes have little or nothing to do with obesity.  In Time's article "If you can't lose weight, don't blame your genes", they site a study that was headed by John Mathers at Newcastle University which was published in the BMJ.  https://www.bmj.com/content/354/bmj.i4707

The study was a review of 9563 participants in eight randomized controlled trials.  The objective was to "
assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomized controlled trials."


The conclusion is that carriers of the gene (FTO minor allele) responded similarly to the rest of the population after weight loss intervention.  In other words, people who carry this gene responded the same as those without the gene after diet, exercise, or drugs.

According to the study:  "Carriage of the FTO minor allele has no effect on the efficacy of lifestyle and drug related weight loss interventions."



The study found no evidence that the FTO Gene does not affect weight loss. 

“We found no evidence at all that FTO genotype affected weight loss,” says Mathers. “It didn’t affect weight loss when we simply looked at kilograms of weight lost, or BMI or waist circumference; however we looked, the FTO genotype did not seem to matter. We think this is good news — carrying the high risk [form of the gene] makes you more likely to be a bit heavier but it shouldn’t prevent you from losing weight. That should encourage people.”

FYI:  When it comes to clinical studies, some are done 'in house' and are not reliable.  Studies that are randomized and controlled are quite reliable, especially when a large number of people are involved. 

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What is a randomized controlled trial?

This is a study in which people are allocated at random (purely by chance alone) to receive one or more clinical interventions. One of these interventions is the standard of comparison or control. The control may be a standard practice, a placebo ("sugar pill"), or no intervention at all.

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